Pathophysiology Of Anemia-Classification, Types of Anemia

Pathophysiology of Anemia-Classification, Types of Anemia

Definition of Anemia –

Anemia is a Blood Disorder, Anemia may be defined as a reduction below normal limits of total circulation red cell-mass. This value is not easily measured , there fore, Anemia has been defined as reduction below normal in the volume of the packed red cells or reduction in the hemoglobin concentration of the blood is called Anemia.

Anemia Value –

  • In Women – 12.0 to 15.0 gm/dl
  • In Men 13.6 to 17.2 gm/dl

Classification of Anemia – 

  • Aplastic Anemia
  • Haemolytic Anemia
  • Megaloblastic Anemia
  • Pernicious Anemia
  • Iron Deficiency Anemia

Anemia Definition and Physiology of Anemia

Anemia Definition and Physiology of Anemia

Pathophysiology Of Anemia – 

Ventricular dysfunction Reduced Arterial Flow


Renal Blood Flow RAAS Activation (Decreased)                                          ⇓  Proinflammatory Cytokine activation

      ⇓                                                                                                                                  ⇓

                    Pro Tubule NA reabsorption Increase                                                        Decrease of Marrow erythropiesis Iron Store                                                                                                                                                          ⇓

                       ⇓                                                                                                 Iron Store available Decrease

Plasma Volume Hemodilution Anemia Increase                                                      RBS Volume Decrase

 ⇓                                                                                                                                      ⇓


Aplastic Anemia – Is a disorder of pluripotent stem cells that leads to bone marrow failure. The disorder features are hypocellular bone marrow and pancytopenia.


  • Idiopathic
  • Chemical agents
  • Ionizing Radiations
  • Drugs – Anti Convulsants, NSAIDS
  • Viruses

Clinical Features –

  • The bone marrow is hypocellular.
  • Bone marrow is largely composed of narrow space populated by fact cells and fibrous strome.
  • Granulocytopena.
  • Mild progressive weakness and fatigue.

Haemolytic Anemia – Is characterized by following features shortening of the normal red cell life span. destruction of red cells.

Types Of Haemolytic Anemia –

  • Hereditary Spherocytosis
  • Sickel Cell Anemia

Megaloblastic Anemia – It constitute a diverse group of entities having in common impairs DNA synthesis and distinctive morphological changes in RBS.

Pernicious Anemia – It is an important causes of Vitamine B12 deficiency. The features that sets pernicious anemia apart from the other vitamins B12 deficiency, megaloblastic Anemia is the causes of the Vitamins B12.

Iron Deficiency Anemia – Iron deficiency is the most common nutritional disorder in the world. The prevalance of iron deficiency anemia is higher in the development countries.  Colour of skin become pale. Hypoxia which leads to weakness and tiredness.

One Comment

  • Averoes says:

    Hemolytic anemia group name is quite rare disease, a common feature of which is the increased destruction of red blood cells, determines, on the one hand, anemia and increased formation of decomposition products of red blood cells, on the other hand – reactively reinforced erythropoiesis

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