Depression – Types Pathophysiology, Biological Marker Symptoms
Depression Types of Disease occurs in Humans, Process of Pathophysiology of Depression, Biological markers of Depression, Signs and Symptoms of Depression check bellow –
Depression – Depression is a disorder a sad mood exceeding normal sadness or grief. Specially the sadness od depression is charaterised by greater intensity and duration and by more severe symptoms and function disabilities than is normal. In Depression symptoms are characterized not only the negative thought, mood and behavior, But they are also specific changes in bodily function Is called Depression Disease.
Types of Depression –
- Major Depression
- Bipolar Disorder (Manic Depression)
Major Depression – This is cause by or characterized by combination pf syndrome. Episodes of depression can occurs once, twice in a day.
Dysthymia – It is a less severe types of depression. It is involved linger term, illness, they got some time patient dysthymia also experience episodes of mania.
Bipolar disorder – It is also called manic depression. Mania of then affects thinking, judgement, social behavior during a manic phase.
Pathophysiology of Depression –
Depression is multi factors and variety of factors such as social. development work together cause depression disorder. Changes during in depression in brain – mono amine neurotransmitters, specifically, Norepinephrin, Serotonin, 5 HT, Dopamaine DA, certain strain full events. medical illness drugs. Some basic factor are display depression of Pathophysiology –
Biological amine hypothesis – Causes inadequate mono amine neurotransmitter most notably NE.
Permissive hypothesis – observation in literature on both NE and 5 HT result of carefully controlled shown anti manic effects of L tryptophan, Low 5 HT.
Post synaptic Changes in Receptors – changes in amine receptors system have emerged. down regulation of beta adrenergic receptors, based on post synaptic changes in receptor sensitivity provided onset of activity of anti depressant drugs.
Dysregulation hypothesis – its diversity of anti depressant activity either adaptive changes occurs in receptor.
5HT / NE Links – both of sterogenic and nor adrenergic systems need to intact for anti depressant effects to extract 5HT, NE.
Role Of Dopamine In Depression
Biological Markers Of Depression –
There is no boilogical markers discovered but some several biological abnormalities are present in many depressed patient. Approximalities 45 to 60% patient major depression have neuroendocrine abnormalities. Rapid eye movement REM, Hypothalamic pituitary adrenal HPA, Dexamethasone suppression Test DST, Thyrotrophin released Hormone TRH.
Signs And Symptoms – Depression Symptoms Of Manic Depression –
- Presisntly sad, anious or empty mood.
- Feeling of hopelessness.
- Insonia, early morning and evening session.
- Decrease of weight, appetite.
- Fatigue and decreased energy.
- Thoughts of suicide and death.
Mania Symptoms Of Manic Depression
- Racing thoughts
- Increase talking
- Increased sexual desire
- Markedly increased energy
- Poor judgment
- Inappropriate social behavior
First steps of obtaining appropriate treatment is a completed physical and psychological evaluation to determine, person may have depressive illness and so. Some question are asking – When did the symptoms starts, How long have they lasted, How severe are they, Have the symptoms occurred before and if so.