Definition Types Causes Agents
Inflammation Profile – Acute & Chronic Inflammation – Definition Types Causes Agents
Inflammation – Inflammation is part of the complex biological response of vascular tissues to harmful stimuli, Such as pathogens, damages cells and finally irritation.
Signs of Inflammation – Rubor – caused by hyperaemia / Heat – caused by hyperaemia / Swelling – Caused by fluid exudation and hyperaemia. / Loss of Function – caused by combined effects of the above.
Types of Inflammation –
- Acute Inflammation
- Chronic Inflammation
Causes of Inflammation –
- After Burn
- Chemical Irritation.
- Infection by pathogens.
- Physical Injury, blunt.
- Immune reaction due to hypersensitivity.
- Ionizing radiation.
Inflammation Types – Dermatitis
Difference Between Acute Inflammation and Chronic Inflammation
Causative Agents – Acute ( Bacterial pathogens, Injured tissues). Chronic ( Presistent acute inflammation due to non degradable pathogens, viral, foreign bodies).
Major Cells involved – Acute ( Neutrophils, Basophils, eosinophils, mono nuclear cells). Chronic – Mono nuclear, Fibroblasts).
Primary Mediators – Vasoactive Amines, Eicosanoids. Chronic – IFN- Alpha and other cytokines, growth factor, reactive oxygen species, hydrolytic enzymes.
Onset – Acute ( Immediate ) , Chronic – (Delayed).
Duration – Few Days on Acute, Chronic – Up to many months or years.
Outcomes – Acute (Healing, abscess formation, Chronic inflammation), Chronic – (Tissue Destruction fibrous).