Acute & Chronic Inflammation – Definition Types Causes Agents

Definition Types Causes Agents

Inflammation Profile – Acute & Chronic Inflammation – Definition Types Causes Agents

Inflammation – Inflammation is part of the complex biological response of vascular tissues to harmful stimuli, Such as pathogens, damages cells and finally irritation.

Signs of Inflammation – Rubor – caused by hyperaemia / Heat – caused by hyperaemia / Swelling – Caused by fluid exudation and hyperaemia. / Loss of Function – caused by combined effects of the above.

Acute and Chronic Inflammation

Acute and Chronic Inflammation

Types of Inflammation – 

  • Acute Inflammation
  • Chronic Inflammation

Inflammation 

Causes of Inflammation – 

  • After Burn
  • Chemical Irritation.
  • Frostbite.
  • Toxins.
  • Infection by pathogens.
  • Physical Injury, blunt.
  • Immune reaction due to hypersensitivity.
  • Ionizing radiation.
  • Stress.
  • Trauma.
  • Alcohols.
  • Foreign.

Inflammation Types – Dermatitis

  • Cystitis
  • Colitis
  • Bursitis
  • Appendicitis
  • Vascuilitis
  • Tonsillitis
  • Rhinitis

Difference Between Acute Inflammation and Chronic Inflammation 

Causative Agents – Acute ( Bacterial pathogens, Injured tissues). Chronic ( Presistent acute inflammation due to non degradable pathogens, viral, foreign bodies).

Major Cells involved – Acute ( Neutrophils, Basophils, eosinophils, mono nuclear cells). Chronic – Mono nuclear, Fibroblasts).

Primary Mediators – Vasoactive Amines, Eicosanoids. Chronic – IFN- Alpha and other cytokines, growth factor, reactive oxygen species, hydrolytic enzymes.

Onset – Acute ( Immediate ) , Chronic – (Delayed).

Duration – Few Days on Acute, Chronic – Up to many months or years.

Outcomes – Acute (Healing, abscess formation, Chronic inflammation), Chronic – (Tissue Destruction fibrous).

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